Science University Research Symposium (SURS)
Publication Date
2024
College
Sciences and Mathematics, College of
Department
Biology, Department of
SURS Faculty Advisor
Andrea Florian, PhD
Presentation Type
Poster Presentation
Abstract
An aggressive blood cancer commonly observed in pediatric patients, Mixed Lineage Leukemia (MLL), has a regulatory MLL complex that promotes histone methyltransferation. Modifying histones utilizing histone methyltransferases like KMT2B (MLL2), is essential for gene expression by regulating transcription. Loss of function and inhibition of KMT2B leads to dysregulation of transcription and therefore promotes MLL tumorigenesis. To improve cancer-targeted therapies, we will use CRISPR interference (CRISPRi) to knock down the expression of KMT2B and measure levels of Rhabdoid tumor cell proliferation and apoptosis. Previous research surrounding the MLL complex suggests that decreased expression of KMT2B will lead to increased levels of apoptosis, outlining the potential for a new cancer-targeted therapy.
Recommended Citation
Edmonds, Karah and Florian, Andrea PhD, "Assessing the Role of KMT2B Knockdown in Rhabdoid Tumorigenesis Utilizing CRISPRi" (2024). Science University Research Symposium (SURS). 156.
https://repository.belmont.edu/surs/156
