Science University Research Symposium (SURS)

Publication Date

2024

College

Sciences and Mathematics, College of

Department

Biology, Department of

SURS Faculty Advisor

Andrea Florian

Presentation Type

Poster Presentation

Abstract

Osteosarcoma is a type of bone cancer that is especially difficult to treat due to its ability to rapidly metastasize, with an average survival rate of 70% if caught before metastasis but 30% after metastasis. The current standard of treatment, if caught before metastasis, is surgery. However, after metastasis, cisplatin is the chemotherapy of choice, which is often ineffective. This study aims to improve treatment strategies by combining a chemotherapy, cisplatin, with curcumin. The supplement used for this study is curcumin, which is a biologically active ingredient in turmeric. Curcumin has shown promising effects in cancer treatment through its ability to induce oxidative stress on cancer cells by inducing mitochondrial damage and increasing reactive oxygen species, ultimately resulting in cell death. This study shows that combining cisplatin and curcumin decreases cell viability in osteosarcoma cells and increases apoptosis compared to either agent alone.

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