Publication Date
2026
Presentation Length
Poster/Gallery presentation
College
College of Sciences & Mathematics
Department
Biology, Department of
Student Level
Undergraduate
Faculty Mentor
Andrea Florian
Presentation Type
Poster
Summary
There is a well-established relationship between cellular metabolism, cancer progression, and treatment response. Metabolic hormones such as insulin and glucagon regulate pathways involved in cell growth, survival, and stress responses and have been linked to tumor development and chemotherapy sensitivity. Understanding how metabolic signaling influences cancer treatment may provide insight into factors that affect therapeutic outcomes. This study aims to investigate how insulin and glucagon affect the susceptibility of colorectal cancer cells (CRC) to the chemotherapeutic agent oxaliplatin. CRC cells were treated with insulin or glucagon and exposed to varying concentrations of oxaliplatin. Cell viability was measured to evaluate treatment effects. Preliminary results suggest that glucagon and insulin have little influence on SW480 cell viability. Conclusions from this study can inform treatment strategies in the clinic.
Recommended Citation
Cohen, Daniella and Florian, Andrea, "A Sweet Spot for Chemotherapy: The Influence of Insulin and Glucagon on Oxaliplatin Sensitivity in Colorectal Cancer Cells" (2026). SPARK Symposium Presentations. 957.
https://repository.belmont.edu/spark_presentations/957
