Cell Size Sorting with Acoustically Aided Microfluidics

Publication Date

2025

Presentation Length

15 minutes

College

College of Sciences & Mathematics

Department

Chemistry and Physics, Department of

Student Level

Undergraduate

SPARK Category

Research

Faculty Advisor

Krista McBride

WELL Core Type

Intellectual Wellness

SPARK Session

Chemistry & Physics II

Presentation Type

Talk/Oral

Summary

Microfluidic (MF) devices use the flow of fluids, like blood, through microscopic channels to test features of the fluid. Microfluidic devices have been adopted in clinical labs due to their conveniently small size, ability to analyze living matter, and their adaptability to many laboratory uses. Sorting cells by size is one application for MF devices, such as in cell purifying for biological research or sperm selection for in vitro fertilization. This work focuses on sorting particles by size using microfluidics and acoustical forces from an ultrasound transducer in a cost effective way. Specifically, the effects of frequency on the amount of particles correctly sorted were explored. The MF devices were created using the embossed foil method. Finished devices were then placed next to an ultrasound transducer for testing. A solution of polystyrene spheres of different sizes in the sub-millimeter range were flowed through the devices. We present a working set-up for particle size sorting.

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