Publication Date
2026
Presentation Length
Poster/Gallery presentation
College
College of Sciences & Mathematics
Department
Biology, Department of
Student Level
Undergraduate
Faculty Mentor
Dr. Andrea Florian
Presentation Type
Poster
Summary
Colorectal cancer is known to be one of the most common forms of cancer in the world. Over time, treatment responses are affected by various metabolic changes along with chemotherapies. Glucagon signaling and Insulin are linked to colorectal cancer and have also been shown to affect tumor growth, as well as the chemotherapy drug response.In this experimental study, the purpose was to determine whether glucagon and insulin decrease the viability of SW480 colorectal cancer cells during cisplatin (CDDP) treatment. CRC cells were treated with cisplatin alone and in combination with either glucagon or insulin, and cell viability was measured to observe the effects these conditions have on the CRC cells.The results show that the implications of these metabolic treatments in combination with cisplatin suggest that metabolic signaling can influence how the SW480 cells respond to chemotherapy.
Recommended Citation
Gabous, Sarah M. and Florian, Andrea, "Effects of Glucagon and Insulin on SW480 Colorectal Cancer Cells in Combination with Cisplatin" (2026). SPARK Symposium Presentations. 1143.
https://repository.belmont.edu/spark_presentations/1143
