Publication Date

2026

Presentation Length

Poster/Gallery presentation

College

College of Sciences & Mathematics

Department

Biology, Department of

Student Level

Undergraduate

Faculty Mentor

Dr. Florian, Dr. Park

Presentation Type

Poster

Summary

Cisplatin is a widely used chemotherapy drug for treating various types of cancer. Although cisplatin is effective in killing cancer, it can also cause toxic side effects in normal tissues. Because cisplatin can cross the placental barrier, its use during pregnancy is generally avoided, particularly during early embryonic stages of fetal development. Exposure to cytotoxic drugs during embryogenesis may lead to developmental abnormalities, birth defects, or pregnancy complications. Understanding how cisplatin affects early development is therefore important.          
       Zebrafish (Danio rerio) are an established model for studying developmental toxicity due to their rapid external development, transparent embryos, and genetic similarity to humans. The objective of this study was to evaluate the effects of cisplatin exposure on zebrafish embryonic development. Embryos were exposed to 0, 10, 50, 100, 200 uM cisplatin in egg water from 3-72 hours post-fertilization (hpf). Hatching rate and morphological abnormalities were recorded and compared across treatment groups. Results showed a dose-dependent increase in developmental toxicity, with higher concentrations of cisplatin leading to delayed hatching, spinal defects, dark yolk sacs, and yolk sac edema. These findings suggest that cisplatin exposure during early embryogenesis can significantly disrupt normal vertebrate development.

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